聂文锋，男，1988年5月生，安徽安庆人，博士，教授、博士生导师，国家重点研发计划首席青年科学家，山东省泰山学者青年专家，研究领域为植物表观遗传学与设施蔬菜生长发育调控。
个人简历：
2024-至今 山东农业大学，园艺科学与工程学院，教授
2020-2024扬州大学园艺系，校拔尖人才，校聘教授
2017-2020中国科学院上海逆境生物学研究中心，助理研究员
2015-2017中国科学院上海生命科学研究院，博士后
2012-2014美国普渡大学，园艺与景观设计系，联合培养博士研究生
2009-2014浙江大学，农业与生物技术学院，蔬菜学博士
2005-2009吉林大学，植物科学学院，园艺学士
主要研究领域与方向
设施蔬菜是我国重要产业，表观遗传调控在设施蔬菜生长发育和抗逆过程中起着重要作用。DNA序列上的甲基化修饰（5mC）和组蛋白H2A.Z变体是两种重要且保守的表观遗传修饰，二者在植物全基因组整体层面相互拮抗而在局部特异性DNA序列上相互协同，进而对植物细胞的基因表达调控产生重要影响。5mC和H2A.Z等表观遗传修饰可充分释放植物表型可塑性的潜力，在调控番茄等蔬菜作物的生长发育、抗逆性和品质形成等过程中发挥重要作用。课题组长期开展设施蔬菜的表观调控及其应用研究，主要研究方向为：
（1）设施蔬菜生态环境大模型构建及其智能化应用，利用AI算法和深度学习在设施环境综合调控中的交叉运用，为设施蔬菜提供绿色优质高效生产的作用方案。
（2）DNA去甲基化介导蔬菜作物代谢网络重编程，结合多组学与人工智能方法，系统性揭示表观遗传与代谢互作规律，为设计营养价值高、抗逆性强的新种质提供策略。
（3）解析组蛋白变体H2A.Z生物学功能与作用机制，研究DNA去甲基化、H2A.Z和组蛋白乙酰化等维持基因组常染色质状态的表观修饰在设施蔬菜生产上的广谱性调控功能。
主要科研项目：
（1）国家重点研发计划，青年科学家项目，北方设施园艺作物减排固碳绿色增效标准化种植技术，2025/11-2028/12，主持；
（2）国家自然科学基金委员会，面上项目，弱光环境下组蛋白H2A.Z变体调控番茄株型的表观遗传机制，2025/01-2028/12，主持；
（3）山东省人才工程，泰山学者青年专家项目，基于DNA去甲基化的番茄表观遗传种质构建及应用研究，2025/01-2027/12，主持；
（4）山东农业大学，人才引进科研启动经费（“冲一流”建设专项经费），2024/09-2029/08主持；
（5）国家自然科学基金委员会，青年科学基金项目，DNA去甲基化酶CsDML4调控水苏糖合成酶基因CsSTS表达和黄瓜果实膨大的机理，2021/01-2023/12主持；
（6）江苏省科学技术厅，江苏省自然科学青年基金项目，组蛋白变体H2A.Z调控番茄植株对亚低温响应的机理，2020/07-2023/06，主持;
（7）国家自然科学基金委员会，面上项目，番茄根结线虫抗性反应中redox介导的温敏性及其调控机制，2013/01-2016/12，参与。
主要学术论文（#为共同第一作者，*为通讯作者）：
(1) Guo, Z.Y., Su, Y.H., Nie, W.F., Li, X.M., Gao, X., Shi, Q.H., and Zhang, Y. Unraveling the effects of mushroom-tomato rotation and oxygenated subsurface drip irrigation on plant growth and development by phenotypic characterization and microbiome profiling in tomato. Sci Hortic, 2025 353.
(2) Li, J., Dong, G., Liu, Y., Yuan, H., Xu, Z., Nie, W.F., Zhang, Y., and Shi, Q. Depth Imaging-Based Framework for Efficient Phenotypic Recognition in Tomato Fruit. Plants, 2025 14.
(3) Nie, W.F.*, Mao, Y.Y., Xin E. and Liu, R.* Actin-related protein ARP4 and ARP6 antagonistically regulate DNA demethylase ROS1 in plants. Plant Physiology, 2024, 195(1):279-282.
(4) Nie, W.F#, Li, Y.#, Chen, Y., Guang, Y., Zhou, Y.,* and Yang, Y.*Spectrum-dependent environmental regulation guides the morphogenesis, architecture, and flowering of pepper plants. Journal of Photochemistry and Photobiology B-Biology, 2023, 241:112673.
(5) Zhou, X.#, Wei, M.#, Nie, W.F.#, Xi, Y., Li, P., Zheng, Tang, Q.,K., Satheesh, V., Wang, Y., Luo, J., Du, X., Liu, R., Yang, Z., La, H., Zhong, Y., Yang, Y., Zhu, J.K., Du, J.* and Lei, M.* The H3K9me2-binding protein AGDP3 limits DNA methylation and transcriptional gene silencing in Arabidopsis. Journal of Integrative Plant Biology, 2022, 64(12):2385-2395.
(6) Xu, A., Wei, N., Zhou, S., Hu, H., Bie, Z., Nie, W.F.*, Cheng, F.*. Thioredoxin h2 inhibits MAPK3 phosphorylation to regulate the CBF2 COR signaling pathway in response to chilling stress in Citrullus lanatus. Horticulture Research, 2022, 10(2):uhac256.
(7) Yang, X, Zhang, X, Yang, Y, Zhang, H, Zhu, W.* and Nie, W.F.*Histone variant Sl_H2A.Z regulates the carotenoids biosynthesis and gene expression during the tomato fruit ripening. Horticulture Research, 2021, 8, 58.
(8) Liu, P. #, Nie W.F. # *, Xiong, X., Wang, Y., Jiang, Y., Huang, P., Lin, X., Qin, G., Huang, H., Niu, Q., Du, J., Lang, Z., Lozano-Duran R. and Zhu, J.K.(*)A novel protein complex that regulates active DNA demethylation in Arabidopsis. Journal of Integrative Plant Biology,2021, doi:10.1111/jipb.13045.
(9) Jiang, Y.#, Ding, X.#, Wang, J., Zou, J. and Nie, W.F.*Decreased low-light regulates plant morphogenesis through the manipulation of hormone biosynthesis in Solanum lycopersicum. Environmental and Experimental Botany,2021, 185.
(10) Nie, W.F.*DNA methylation: from model plants to vegetable crops. Biochemical Society Transactions, 2021, BST20210353. doi: https://doi.org/10.1042/BST20210353
(11) Wang, J.#, Feng, Y.#, Ding, X.#, Huo, J., Nie, W.F.* Identification of long non-coding RNAs associated with tomato fruit expansion and ripening by strand-specific paired-end RNA Sequencing. Horticulturae, 2021, 7, 522.
(12) Yang, X.#, Liu, Y.#, Zhang, H.#, Wang, J., Zinta, G., Xie, S., Zhu W.* and Nie, W.F.* Genome-wide identification of circular RNAs in response to low-temperature stress in tomato leaves. Frontiers in Genetics, 2020, 11.
(13) Nie, W.F.#, Lei, M. #, Zhang, M., Tang, K., Huang, H., Zhang, C., Miki, D., Liu, P., Yang, Y., Wang, X., Zhang, H., Lang, Z., Liu, N., Xu, X., Yelagandula, R., Zhang, H., Wang, Z., Chai, X., Andreucci, A., Yu, J.Q., Berger, F., Lozano-Duran, R. and Zhu, J.K.*. Histone acetylation recruits the SWR1 complex to regulate active DNA demethylation in Arabidopsis. Proc Natl Acad Sci USA, 2019, 116 (33): 16641-16650.
(14) Nie W.F.*, Wang M.M., Xia X.J., Zhou Y.H., Shi K., Chen Z.X. and Yu J.Q. (*). Silencing of tomato RBOH1 and MPK2 abolishes brassinosteroid-induced H2O2 generation and stress tolerance, Plant Cell and Environment, 2013, 36: 789-803.
(15) 聂文锋*; 王金玉; 高春娟; 陈学好*; 表观遗传修饰调控园艺植物果实发育的研究进展, 园艺学报, 2022, 49 (3): 671-686.
(16) Lei, M.#, La, H.G.#, Lu, K., Wang, P., Miki, D., Ren, Z., Duan, C.G., Wang, X., Tang, K., Zeng, L., Yang, L., Zhang, H., Nie, W.F., Liu, P., Zhou, J., Liu, R., Zhong, Y., Liu, D. and Zhu, J.K.* Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns. Proc Natl Acad Sci USA, 2014, 111, 527-532
(17) Lang, Z.#, Lei, M.#, Wang, X., Tang, K., Miki, D., Zhang, H., Mangrauthia, S., Liu, W., Nie, W.F., Ma, G., Yan, J., Duan, C.G., Hsu, C.C., Wang, C., Tao, W., Gong, Z. and Zhu, J.K.* The methyl-CpG-binding protein MBD7 prevents DNA hypermethylation and transcriptional gene silencing by facilitating active DNA demethylation. Molecular Cell, 2015, 57, 971-983.
(18) Yang, Y., La, H., Tang, K., Miki, D., Yang, L., Wang, B., Duan, C.G., Nie, W.F., Wang, X., Wang, S., Pan, Y., Tran, E.J., An, L., Zhang, H.* and Zhu, J.K.* SAC3B, a central component of the mRNA export complex TREX-2, is required for prevention of epigenetic gene silencing in Arabidopsis. Nucleic Acids Research, 2017, 45, 181-197.
(19) Yang, Y.#, Tang, K.#, Datsenka, T.U.#, Liu, W., Lv, S., Lang, Z., Wang, X., Gao, J., Wang, W., Nie, W.F., Chu, Z., Zhang, H., Handa, A. K., Zhu, J. K. and Zhang, H. Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome. Journal of Integrative Plant Biology, 2019, 61(12): 1224-1242
(20) Zhao, C.Z.#*, Jiang, W.#, Zayed, O.#, Liu, X., Tang, K., Nie, W.F., Li, Y.L., Xie, S.J., Li, Y., Long, T.D., Liu, L. L., Zhu, Y.F., Zhao, Y. and Zhu, J.K.* The LRXs-RALFs-FER module controls plant growth and salt stress responses by modulating multiple plant hormones. National Science Review, 2021, 8
(21) Huang, P.#, Huang, H.#, Lin, X.Q., Liu, P., Zhao, L., Nie, W.F., Zhu, J.K., and Lang, Z.B. MSI4/FVE is required for accumulation of 24-nt siRNAs and DNA methylation at a subset of target regions of RNA-directed DNA methylation. Plant Journal, 2021, 108, 347-357.
(22) Wang, Z.#, Wang M.#, Yang, C., Zhao, L., Qin, G., Peng, L., Zheng, Q., Nie, W.F., Song, C.P., Shi, H., Zhu, J.K.* and Zhao, C.*. SWO1 modulates cell wall integrity under salt stress by interacting with importin ɑ in Arabidopsis. Stress Biology, 2021, 1:9
联系方式：
nwf2024@sdau.edu.cn，泰安市文化路44号
